Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016 Oct 06; 167(2):419-432.e16. Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA. PMID: 27693353; PMCID: PMC5072533.
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Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics. Sci Signal. 2016 Apr 19; 9(424):rs3. Roybal KT, Buck TE, Ruan X, Cho BH, Clark DJ, Ambler R, Tunbridge HM, Zhang J, Verkade P, Wülfing C, Murphy RF. PMID: 27095595; PMCID: PMC4871116..
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Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11; 164(4):780-91. Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. PMID: 26830878; PMCID: PMC4752866.
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Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. 2016 Feb 11; 164(4):770-9. Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA. PMID: 26830879; PMCID: PMC4752902.
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Cellular Structures Controlling T Cell Signaling in Time and Space. Encyclopedia of Cell Biology. 2016 Jan 1; 677-686. Wülfing WC, Roybal KT.
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Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science. 2015 Oct 16; 350(6258):aab4077. Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA. PMID: 26405231; PMCID: PMC4721629.
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Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling. PLoS One. 2015; 10(8):e0133231. Roybal KT, Mace EM, Clark DJ, Leard AD, Herman A, Verkade P, Orange JS, Wülfing C. PMID: 26237588; PMCID: PMC4523178.
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Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network. PLoS One. 2015; 10(8):e0133299. Roybal KT, Mace EM, Mantell JM, Verkade P, Orange JS, Wülfing C. PMID: 26237050; PMCID: PMC4523204.
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Synthetic biology approaches to engineer T cells. Curr Opin Immunol. 2015 Aug; 35:123-30. Wu CY, Rupp LJ, Roybal KT, Lim WA. PMID: 26218616; PMCID: PMC4553068.
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Cellular structures controlling T cell signaling in time and space. Encyclopedia of Cell Biology. 2015; 677-686. Wülfing C, Roybal KT.
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IFN-α suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells. J Immunol. 2014 Jun 15; 192(12):5687-94. Huber JP, Gonzales-van Horn SR, Roybal KT, Gill MA, Farrar JD. PMID: 24813204; PMCID: PMC4104489.
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Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors. MAbs. 2014 Jan-Feb; 6(1):108-18. Furlan SN, Mandraju R, Brewer T, Roybal K, Troutman TD, Hu W, Palm NW, Unni A, Pasare C. PMID: 24284965;PMCID: PMC3929435.
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The actin-driven spatiotemporal organization of T-cell signaling at the system scale. Immunol Rev. 2013 Nov; 256(1):133-47. Roybal KT, Sinai P, Verkade P, Murphy RF, Wülfing C. PMID: 24117818.
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Differential regulation of the period genes in striatal regions following cocaine exposure. PLoS One. 2013; 8(6):e66438. Falcon E, Ozburn A, Mukherjee S, Roybal K, McClung CA. PMID: 23776671; PMCID: PMC3679086.
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New TACTICS for finding Numb. Immunol Cell Biol. 2013 Jan; 91(1):1-2. Roybal KT, Wülfing C. PMID: 23183270.
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Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages. Appl Environ Microbiol. 2012 Oct; 78(19):6829-37. Eitson JL, Medeiros JJ, Hoover AR, Srivastava S, Roybal KT, Aínsa JA, Hansen EJ, Gumbo T, van Oers NS. PMID: 22820329; PMCID: PMC3457510.
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The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse. J Immunol. 2011 Jun 15; 186(12):6839-47. DeFord-Watts LM, Dougall DS, Belkaya S, Johnson BA, Eitson JL, Roybal KT, Barylko B, Albanesi JP, Wülfing C, van Oers NS. PMID: 21543646; PMCID: PMC3110614.
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Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy. Commun Integr Biol. 2010 Nov; 3(6):545-8. Sinai P, Roybal KT, Wülfing C. PMID: 21331235.
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Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function. Sci Signal. 2010 Jul 27; 3(132):pe24. Roybal KT, Wülfing C. PMID: 20664063.
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Spatiotemporal patterning during T cell activation is highly diverse. Sci Signal. 2009 Apr 07; 2(65):ra15. Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C. PMID: 19351954.
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Spatiotemporal patterning of T cell signaling as an important regulator of T cell activation at the systems level. The FASEB Journal. 2008 Mar 1; 22:1064.16-1064.16. Christoph Wuelfing, Kentner L. Singleton, Kole T. Roybal, Yi Sun. .
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Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci USA. 2007 Apr 10; 104(15):6406-11. Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA, McClung CA. PMID: 17379666.
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