Publications

Links to all papers from the lab are organized by year of publication.

  • Hyrenius-Wittsten A, Su Y, Park M, Garcia JM, Alavi J, Perry N, Montgomery G, Liu B, Roybal KT. SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models. Sci Transl Med. 2021 Apr 28;13(591):eabd8836. doi: 10.1126/scitranslmed.abd8836. PMID: 33910981.

    View in PubMed | Press: Fierce Biotech, STAT, New Scientist, Nature Reviews Immunology

  • Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, Cardarelli L, Troyanskaya O, Sidhu SS, Roybal KT, Okada H, Lim WA. SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma. Sci Transl Med. 2021 Apr 28;13(591):eabe7378. doi: 10.1126/scitranslmed.abe7378. PMID: 33910979.


    View in: PubMed | Press: STAT, New Scientist, Nature Reviews Immunology

  • DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation. Nat Nanotechnol. 2020 Dec 14. Huang X, Williams JZ, Chang R, Li Z, Burnett CE, Hernandez-Lopez R, Setiady I, Gai E, Patterson DM, Yu W, Roybal KT, Lim WA, Desai TA. PMID: 33318641.

    View in: PubMed  
       
  • Precise T cell recognition programs designed by transcriptionally linking multiple receptors. Science. 2020 Nov 27; 370(6520):1099-1104. Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA. PMID: 33243890.

     

    View in: PubMed | Press: STAT, New Scientist

  • IMMU-33. MULTI-ANTIGEN RECOGNITION CIRCUITS OVERCOME CHALLENGES OF SPECIFICITY, HETEROGENEITY, AND DURABILITY IN T-CELL THERAPY FOR GLIOBLASTOMA. Neuro-Oncology. 2020 Nov 9; 22(Supplement_2):ii111-ii112. Payal Watchmaker, Joseph Choe, Milos Simic, Ryan Gilbert, Aileen li, Nira Krasnow, Diego Carrera, Wei Yu, Kira Downey, Anna Celli, Juhyun Cho, Jessica Briones, Ruth Dannenfelser, Lia Cardarelli, Sachdev Sidhu, Kole Roybal, Wendell Lim, Hideho Okada.

     

    View in: Publisher Site

  • MM-378: Inhibitory and Stimulatory Interplay Between Myeloma Tumor and T Cells. Clinical Lymphoma Myeloma & Leukemia. 2020 Sep 1; 20:s309. August Dietrich, Cassandra Burnett, Thomas Martin, Arun Wiita, Kole Roybal, Justin Eyquem. .

    View in: Publisher Site

  • CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Blood Adv. 2020 Jul 14; 4(13):2899-2911. Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M. PMID: 32589729.

    View in: PubMed 
     
  • convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting. Commun Biol. 2020 Jun 09; 3(1):296. Landgraf KE, Williams SR, Steiger D, Gebhart D, Lok S, Martin DW, Roybal KT, Kim KC. PMID: 32518350.

    View in: PubMed   

  • Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 04 30; 181(3):728-744.e21. Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. PMID: 32302591.

     

    View in: PubMed   
  • IMMU-21. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi123-vi123. Payal Watchmaker, Joseph Choe, Diego Carrera, Ryan Gilbert, Wei Yu, Kira Downey, Kole Roybal, Wendell Lim, Hideho Okada. .

    View in: Publisher Site

     

  • Paving New Roads for CARs. Trends Cancer. 2019 10; 5(10):583-592. Hyrenius-Wittsten A, Roybal KT. PMID: 31706506.

    View in: PubMed   

     

  • NextGen cell-based immunotherapies in cancer and other immune disorders. Curr Opin Immunol. 2019 08; 59:79-87. Azimi CS, Tang Q, Roybal KT, Bluestone JA. PMID: 31071513.

    View in: PubMed   

     

  • Clonal Deletion of Tumor-Specific T Cells by Interferon-? Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade. Immunity. 2019 02 19; 50(2):477-492.e8. Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, Oh DY, Daud A, Tsai KK, Wu C, Zhang L, Fasso M, Sachidanandam R, Jayaprakash A, Lin I, Casbon AJ, Kinsbury GA, Fong L. PMID: 30737146.

    View in: PubMed   

     

  • Beyond the TCR, Antigen Discrimination in T Cells Continues in the LAT:GRB2:SOS Protein Condensate. Biophysical Journal. 2019 Feb 1; 116(3):530a. Shalini T. Low-Nam, Jenny JY Lin, Darren B. McAffee, Steven A. Alvarez, Scott D. Hansen, Kole T. Roybal, Jay T. Groves.

     

    View in: Publisher Site
  • Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Annu Rev Immunol. 2017 04 26; 35:229-253. PMID: 28446063.

    View in: PubMed   

  • CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Sci Rep. 2017 04 07; 7(1):737. PMID: 28389661.

     

    View in: PubMed   
  • Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016 Oct 06; 167(2):419-432.e16. PMID: 27693353.

    View in: PubMed   

     

  • Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics. Sci Signal. 2016 Apr 19; 9(424):rs3. PMID: 27095595.

    View in: PubMed  

  • Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11; 164(4):780-91. PMID: 26830878.

    View in: PubMed   

     

  • Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. 2016 Feb 11; 164(4):770-9. PMID: 26830879.

    View in: PubMed   

     

  • Cellular Structures Controlling T Cell Signaling in Time and Space. Encyclopedia of Cell Biology. 2016 Jan 1; 677-686. C. Wülfing, K.T. Roybal. .

    View in: Publisher Site

     

  • Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science. 2015 Oct 16; 350(6258):aab4077. PMID: 26405231.

    View in: PubMed   

     

  • Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling. PLoS One. 2015; 10(8):e0133231. PMID: 26237588.

    View in: PubMed   

     

  • Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network. PLoS One. 2015; 10(8):e0133299. PMID: 26237050.

    View in: PubMed   

     

  • Synthetic biology approaches to engineer T cells. Curr Opin Immunol. 2015 Aug; 35:123-30. PMID: 26218616.

    View in: PubMed   

     

  • Cellular structures controlling T cell signaling in time and space. Encyclopedia of Cell Biology. 2015; 677-686. Wülfing C, Roybal KT.

    View Publication

     

  • IFN-a suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells. J Immunol. 2014 Jun 15; 192(12):5687-94. PMID: 24813204.

    View in: PubMed   

     

  • Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors. MAbs. 2014 Jan-Feb; 6(1):108-18. PMID: 24284965.

    View in: PubMed   

     

  • The actin-driven spatiotemporal organization of T-cell signaling at the system scale. Immunol Rev. 2013 Nov; 256(1):133-47. PMID: 24117818.

    View in: PubMed   

     

  • Differential regulation of the period genes in striatal regions following cocaine exposure. PLoS One. 2013; 8(6):e66438. PMID: 23776671.

    View in: PubMed   

     

  • New TACTICS for finding Numb. Immunol Cell Biol. 2013 Jan; 91(1):1-2. PMID: 23183270.

    View in: PubMed   

     

  • Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages. Appl Environ Microbiol. 2012 Oct; 78(19):6829-37. PMID: 22820329.

    View in: PubMed   

     

  • The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse. J Immunol. 2011 Jun 15; 186(12):6839-47. PMID: 21543646.

    View in: PubMed   

     

  • Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy. Commun Integr Biol. 2010 Nov; 3(6):545-8. Sinai P, Roybal KT, Wülfing C. PMID: 21331235.

    View in: PubMed

     

  • Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function. Sci Signal. 2010 Jul 27; 3(132):pe24. Roybal KT, Wülfing C. PMID: 20664063.

    View in: PubMed   

     

  • Spatiotemporal patterning during T cell activation is highly diverse. Sci Signal. 2009 Apr 07; 2(65):ra15. Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C. PMID: 19351954.

    View in: PubMed   

     

  • Spatiotemporal patterning of T cell signaling as an important regulator of T cell activation at the systems level. The FASEB Journal. 2008 Mar 1; 22:1064.16-1064.16. Christoph Wuelfing, Kentner L. Singleton, Kole T. Roybal, Yi Sun. .

    View in: Publisher Site

  • Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6406-11. Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA, McClung CA. PMID: 17379666.

     

    View in: PubMed   

Featured In

News

Media highlights of Kole and the lab’s research.
'Smart' immune cells kill tumours and stop them regrowing in mice
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Attacking glioblastoma and other solid tumors with CAR-Ts that target multiple antigens
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Tweaking Mother Nature, biologists aim for better cancer-fighting cells
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'Cell Bots' Chase Down Cancer, Deliver Drugs Directly to Tumors
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Synthetic Notch receptors were featured in Notable Advances 2016
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Kole Roybal receives the inaugural Sartorius & Science Magazine Prize in Regenerative Medicine and Cell Therapy 2018
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Boosting the immune system to fight cancer
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Cell Design Labs, Little Partner Of Kite Pharma, Pushes T-Cell Engineering Frontier
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Videos

Recent media featuring Roybal Lab
Engineering T cells with Customized Therapeutic Response Programs with Synthetic Notch Receptors
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Synthetic Notch Receptors and T cells with Combinatorial Antigen-Sensing Circuits
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Stay Updated

Keep up-to-date with the latest research from the Roybal lab.

@dnatieclub is excited to host Daniel Goodman @dbgoodman on Breakthroughs in Cell Therapies, CRISPR,... and Synbio

Tune in for a conversation hosted by @EganPeltan and @elkingtonxy this Wed. at 8 pm PT on Clubhouse:

https://www.clubhouse.com/join/dnatie/S0AhDdZu/xoNRjlK5

@MarsonLab @KoleRoybal @UCSF @parkerici

So, some news: I’m unreasonably excited to be joining the all-star team at @Arsenalbio as CSO ... (1/n) https://twitter.com/ArsenalBio/status/1417110231457402885

Congratulations to the extremely talented postdoc @dbgoodman and grad student @CamilliaAzimi in the... @roybal_lab on their new tour de force preprint on multiplexed CAR engineering for NextGen T cell therapies in collaboration with @MarsonLab + @kickassscience1. Tweetorial below.

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