Hacking Immune Cells To Expand Their Therapeutic Potential
In the Roybal Lab, we harness the tools of synthetic and chemical biology to enhance the therapeutic potential of engineered immune cells. We take a comprehensive approach to cellular engineering by developing new synthetic receptors, signal transduction cascades, and cellular response programs to enhance the safety and effectiveness of adoptive cell therapies. We also study the logic of natural cellular signaling systems, and the underlying principles of cellular communication and collective cell behavior during an immune response. These interests are complementary as cell engineering is often informed by knowledge obtained from studying natural mechanisms of cell regulation refined by evolution.
The Roybal Lab is a dedicated group of students, post-docs, physicians, and staff scientists with diverse backgrounds ranging from basic science to cellular engineering and synthetic immunology. Each member brings expertise in their field to our unique and highly collaborative research environment.
Media highlights of Roybal Lab's research.
Recent Lab News
Make sure to register and attend the IgEquity Symposium on Oct 22! Camillia and Casey founded this organization years ago to support gender equity in immunology, and Julie has since served as director. It’s an exceptional event with top notch speakers such as Akiko Iwasaki, don’t miss out!
September 20th through 27th is Postdoc appreciation week in the Roybal Lab! Dan G., Dan P., Ray, and Joe, thank you for your enduring patience, enthusiasm, and willingness to mentor the Roybal lab PhD students and Staff Scientists. We hope you enjoyed your night out!
Kole is now a tenured Associate Professor of Microbiology and Immunology at UCSF. Congratulations on this well-deserved promotion. This is a huge milestone and we are so proud of you!
Joe Muldoon (co-advised by Justin Eyquem and Kole Roybal) received a Cancer Research Institute (CRI) Irvington Postdoctoral Fellowship this month. Go Joe!
Also, this summer we welcome Maria Chirinos as an undergraduate researcher in the Roybal Lab. Maria is a biology student at CCSF with plans to transfer to U.C. Berkeley and complete a B.S. in cell and molecular biology. She is working on shRNA validation for targets associated with T cell activation.