‘Smart’ immune cells kill tumours and stop them regrowing in mice
Attacking glioblastoma and other solid tumors with CAR-Ts that target multiple antigens
Modular design of synthetic receptors for programmed gene regulation in cell therapies
Engineering T cells with Customized Therapeutic Response Programs with Synthetic Notch Receptors
Synthetic Notch Receptors and T cells with Combinatorial Antigen-Sensing Circuits
Tweaking Mother Nature, biologists aim for better cancer-fighting cells
‘Cell Bots’ Chase Down Cancer, Deliver Drugs Directly to Tumors
Synthetic Notch receptors were featured in Notable Advances 2016
Kole Roybal receives the inaugural Sartorius & Science Magazine Prize in Regenerative Medicine and Cell Therapy 2018
A New Platform for Fully Customizable Transcriptional Receptors.
Synthetic biology has established powerful tools for precise and complex control of cellular function. Engineering such systems to meet clinical requirements remains challenging but has enormous implications for the successful treatment of human disease. Here, we adopted a clinically driven design process to build and test receptors for the autonomous control of therapeutic cells. We […]